Update on the cell systems available for hepatotoxic prediction in the AOP era Back
Prediction of hepatotoxicity remains a challenge nowadays. Focusing on the mechanisms instead of relying on generic readouts (cell death free radicals...) is the way to go and implies using cell systems that are shown to have intact molecular pathways for a given mechanism. In parallel the progress in cell biology that deliver new models derived from the iPSC or new culture methods such as 3D or flow through devices make available many new assay systems. And the question is: Which is the relevant system for addressing a certain hepatotoxicity project? The session will cover those new systems that are commercially available together with their relevance for predicting issues related to genotoxicity, reactive metabolites and cholestasis.